Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1234)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0142790	0.0998205	0.8876166
Weighted median	23	-0.0118150	0.0549249	0.8296798
Inverse variance weighted	23	-0.0201482	0.0390156	0.6055657
Simple mode	23	-0.0981550	0.1004164	0.3389588
Weighted mode	23	-0.0336997	0.0825743	0.6871352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.90924	21	0.7747289
Inverse variance weighted	15.91332	22	0.8201645

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003604	0.0056424	0.9496711

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004903	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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