Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1233)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0741541	0.0998204	0.4657867
Weighted median	23	0.0466362	0.0561231	0.4059950
Inverse variance weighted	23	0.0254702	0.0390156	0.5138712
Simple mode	23	0.0393691	0.0943697	0.6805902
Weighted mode	23	0.0758076	0.0760396	0.3296292

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.72560	21	0.7848653
Inverse variance weighted	16.90128	22	0.7687868

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061179	0.0056423	0.2905282

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005251	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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