Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1232)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1893464	0.1120843	0.1059518
Weighted median	23	0.0594792	0.0570503	0.2971455
Inverse variance weighted	23	-0.0060450	0.0463130	0.8961510
Simple mode	23	-0.0600350	0.0893367	0.5085747
Weighted mode	23	0.0602964	0.0655259	0.3674527

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.47724	21	0.1888332
Inverse variance weighted	30.99968	22	0.0961221

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.011999	0.0063355	0.072095

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00094	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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