Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1231)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0891851	0.1036392	0.3992130
Weighted median	23	-0.0717195	0.0601161	0.2328629
Inverse variance weighted	23	-0.0130216	0.0401730	0.7458345
Simple mode	23	-0.1263768	0.1096540	0.2614834
Weighted mode	23	-0.1009293	0.0810510	0.2261383

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.63795	21	0.3635815
Inverse variance weighted	23.32512	22	0.3835701

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046772	0.0058582	0.4335732

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007102	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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