Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1230)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1928414	0.1039861	0.0777661
Weighted median	23	-0.1326349	0.0549761	0.0158396
Inverse variance weighted	23	-0.0444356	0.0419210	0.2891521
Simple mode	23	-0.1558309	0.1047448	0.1510190
Weighted mode	23	-0.1527036	0.0599686	0.0183983

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.79017	21	0.3552672
Inverse variance weighted	25.39920	22	0.2783680

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0091137	0.0058779	0.135959

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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