Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 123)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0066863	0.1168784	0.9549208
Weighted median	23	0.0010735	0.0602861	0.9857934
Inverse variance weighted	23	0.0007871	0.0446377	0.9859317
Simple mode	23	-0.0452390	0.0900770	0.6204982
Weighted mode	23	-0.0254303	0.0594361	0.6729128

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.79068	21	0.1191183
Inverse variance weighted	28.79729	22	0.1507397

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004589	0.0066065	0.9452745

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008726	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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