Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1229)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1205470	0.0998206	0.2406128
Weighted median	23	-0.0253749	0.0540327	0.6386259
Inverse variance weighted	23	0.0077677	0.0390155	0.8421903
Simple mode	23	-0.0585409	0.0920302	0.5312705
Weighted mode	23	-0.0692271	0.0621012	0.2769895

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.90888	21	0.7166145
Inverse variance weighted	18.85923	22	0.6540046

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078798	0.0056424	0.1771371

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005727	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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