Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1228)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2001717	0.1129171	0.0907806
Weighted median	23	0.0194348	0.0599450	0.7457789
Inverse variance weighted	23	0.0324870	0.0479896	0.4984321
Simple mode	23	0.1847611	0.1229705	0.1471914
Weighted mode	23	-0.0682009	0.0725511	0.3574052

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.87275	21	0.1751050
Inverse variance weighted	33.28501	22	0.0579757

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0142875	0.0063826	0.0361483

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010296	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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