Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1227)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0935861	0.1012144	0.3656614
Weighted median	23	-0.0627077	0.0539710	0.2452846
Inverse variance weighted	23	-0.0593130	0.0390157	0.1284522
Simple mode	23	-0.0217619	0.0861741	0.8029729
Weighted mode	23	-0.0577134	0.0628808	0.3686656

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.59055	21	0.4234240
Inverse variance weighted	21.72970	22	0.4761181

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021047	0.0057211	0.7166427

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007285	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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