Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1226)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0604064	0.1272937	0.6400099
Weighted median	23	0.0785100	0.0644936	0.2234788
Inverse variance weighted	23	0.0526377	0.0496755	0.2893123
Simple mode	23	0.1565316	0.1100964	0.1691158
Weighted mode	23	0.0844596	0.0774976	0.2875794

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.15093	21	0.0349136
Inverse variance weighted	35.66472	22	0.0329740

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006942	0.0071952	0.3456214

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011359	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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