Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1225)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1783726	0.1123672	0.1273639
Weighted median	23	0.0947300	0.0576168	0.1001474
Inverse variance weighted	23	0.0589512	0.0442509	0.1827934
Simple mode	23	0.0089895	0.1152134	0.9385136
Weighted mode	23	0.0837927	0.0729124	0.2628044

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.61204	21	0.1840664
Inverse variance weighted	28.30148	22	0.1659038

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073337	0.0063516	0.2612135

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009267	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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