Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1224)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0631552	0.1060154	0.5577309
Weighted median	23	0.0396871	0.0576610	0.4912741
Inverse variance weighted	23	-0.0100778	0.0407684	0.8047568
Simple mode	23	-0.0474305	0.1169891	0.6890796
Weighted mode	23	0.0586633	0.0877146	0.5105820

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.68786	21	0.3084271
Inverse variance weighted	24.02158	22	0.3460991

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032595	0.0059925	0.592221

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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