Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1223)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0123640	0.0998938	0.9026734
Weighted median	23	-0.0016844	0.0579251	0.9768011
Inverse variance weighted	23	-0.0309116	0.0390154	0.4281901
Simple mode	23	-0.1494529	0.1015682	0.1553291
Weighted mode	23	-0.0206214	0.0763619	0.7896397

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.03093	21	0.4570566
Inverse variance weighted	21.07168	22	0.5163119

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001139	0.0056465	0.8420767

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006575	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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