Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1222)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0428545	0.1129358	0.7081573
Weighted median	23	-0.0092002	0.0563729	0.8703597
Inverse variance weighted	23	0.0283780	0.0431466	0.5107234
Simple mode	23	0.0720121	0.0915621	0.4399743
Weighted mode	23	0.0072929	0.0595602	0.9036574

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.88053	21	0.1748427
Inverse variance weighted	26.90535	22	0.2148433

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000889	0.0063837	0.890571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008313	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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