Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1221)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1396024	0.1067827	0.2052277
Weighted median	23	-0.0387133	0.0551585	0.4827690
Inverse variance weighted	23	-0.0562358	0.0444649	0.2059709
Simple mode	23	-0.0824864	0.1055390	0.4427963
Weighted mode	23	-0.0073028	0.0603326	0.9047566

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.03159	21	0.2915306
Inverse variance weighted	28.57471	22	0.1574082

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0120263	0.0060358	0.059476

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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