Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1220)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0744563	0.0998203	0.4639943
Weighted median	23	0.0293348	0.0548958	0.5930843
Inverse variance weighted	23	0.0101680	0.0390156	0.7943900
Simple mode	23	0.0365443	0.0945012	0.7026876
Weighted mode	23	0.0429913	0.0630606	0.5025147

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.52593	21	0.6155224
Inverse variance weighted	19.37423	22	0.6221199

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051968	0.0056423	0.3674932

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005891	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8