Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1219)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0589156	0.1220771	0.6343654
Weighted median	23	0.0239129	0.0643128	0.7100258
Inverse variance weighted	23	-0.0595717	0.0466189	0.2013047
Simple mode	23	0.0631281	0.1273037	0.6248925
Weighted mode	23	0.0968886	0.0854609	0.2691164

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.41304	21	0.0670533
Inverse variance weighted	31.41309	22	0.0879673

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-4.03e-05	0.0069006	0.9953963

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010223	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8