Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1218)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0139863	0.0998207	0.8899051
Weighted median	23	0.0072319	0.0584245	0.9014883
Inverse variance weighted	23	-0.0102847	0.0390155	0.7920834
Simple mode	23	0.0935445	0.0890986	0.3051616
Weighted mode	23	0.0060427	0.0716429	0.9335453

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.46966	21	0.4917115
Inverse variance weighted	20.47129	22	0.5535854

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002273	0.0056423	0.9682451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006224	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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