Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1217)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1703620	0.1166794	0.1590657
Weighted median	23	0.0114185	0.0596435	0.8481769
Inverse variance weighted	23	0.0463116	0.0459502	0.3135194
Simple mode	23	-0.0977392	0.0993374	0.3358569
Weighted mode	23	-0.0174340	0.0728528	0.8130851

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.69301	21	0.1215689
Inverse variance weighted	30.51592	22	0.1064545

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007618	0.0065953	0.2610411

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009673	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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