Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1216)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1527982	0.0998206	0.1407623
Weighted median	23	-0.0282140	0.0563795	0.6167725
Inverse variance weighted	23	-0.0143165	0.0390156	0.7136607
Simple mode	23	-0.0232311	0.0923067	0.8036298
Weighted mode	23	-0.0462423	0.0606799	0.4541116

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.92739	21	0.7154980
Inverse variance weighted	19.19905	22	0.6330067

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085041	0.0056423	0.1466556

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005859	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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