Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1215)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0697632	0.0998190	0.4922852
Weighted median	23	-0.0692411	0.0559855	0.2161732
Inverse variance weighted	23	-0.0482748	0.0390154	0.2159658
Simple mode	23	-0.0632407	0.1061448	0.5573918
Weighted mode	23	-0.0761484	0.0708145	0.2938824

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.58929	21	0.7356820
Inverse variance weighted	16.64399	22	0.7826922

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013196	0.0056423	0.8173443

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005508	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8