Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1214)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1957993	0.1098286	0.0890871
Weighted median	23	-0.1467533	0.0555179	0.0082090
Inverse variance weighted	23	-0.0859578	0.0431034	0.0461280
Simple mode	23	-0.1061312	0.1028157	0.3131712
Weighted mode	23	-0.1578136	0.0621129	0.0186277

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.42335	21	0.2292945
Inverse variance weighted	26.85262	22	0.2168777

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067454	0.0062081	0.2895494

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8