Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1213)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0937331	0.0998207	0.3583990
Weighted median	23	-0.0661816	0.0545557	0.2250911
Inverse variance weighted	23	-0.0442144	0.0390156	0.2571090
Simple mode	23	-0.0738060	0.0924587	0.4332531
Weighted mode	23	-0.0791690	0.0613635	0.2103904

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.30172	21	0.8562937
Inverse variance weighted	14.59218	22	0.8791373

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030409	0.0056423	0.5955902

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004811	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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