Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1212)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2020303	0.1187929	0.1037637
Weighted median	23	0.1549539	0.0590329	0.0086681
Inverse variance weighted	23	0.0978598	0.0463340	0.0346819
Simple mode	23	0.0892089	0.1027679	0.3947313
Weighted mode	23	0.1596440	0.0685335	0.0294152

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.74330	21	0.0972691
Inverse variance weighted	31.02881	22	0.0955274

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063972	0.0067149	0.3515819

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011309	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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