Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1211)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0643444	0.0998200	0.5261631
Weighted median	23	0.0464807	0.0555715	0.4029230
Inverse variance weighted	23	0.0260584	0.0390156	0.5041986
Simple mode	23	0.0667081	0.0936396	0.4837096
Weighted mode	23	0.0639579	0.0733213	0.3924680

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.36829	21	0.7486146
Inverse variance weighted	17.33640	22	0.7445284

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055516	0.0056423	0.3363512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005389	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8