Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1210)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0734525	0.0998207	0.4699654
Weighted median	23	0.0262789	0.0548498	0.6318624
Inverse variance weighted	23	0.0382407	0.0390156	0.3270179
Simple mode	23	-0.0360186	0.0946235	0.7071125
Weighted mode	23	0.0212690	0.0627225	0.7377529

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.18506	21	0.573270
Inverse variance weighted	19.33193	22	0.624752

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021623	0.0056423	0.7053963

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006149	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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