Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 121)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1363411	0.0998188	0.1864262
Weighted median	23	0.0744731	0.0560265	0.1837660
Inverse variance weighted	23	0.0602833	0.0390151	0.1223150
Simple mode	23	0.0685731	0.1043469	0.5178919
Weighted mode	23	0.1706802	0.0682461	0.0203249

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.43715	21	0.6842907
Inverse variance weighted	18.12242	22	0.6987058

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046707	0.0056423	0.4170869

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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