Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1209)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0832473	0.1034393	0.4299566
Weighted median	23	0.0282768	0.0574003	0.6222774
Inverse variance weighted	23	0.0074710	0.0403455	0.8530921
Simple mode	23	0.0262038	0.0976399	0.7909131
Weighted mode	23	0.0449067	0.0689691	0.5217169

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.55033	21	0.3684139
Inverse variance weighted	23.52521	22	0.3725993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005571	0.0058469	0.3515229

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000714	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8