Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1208)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0618132	0.1101022	0.5804562
Weighted median	23	0.0545777	0.0543101	0.3149317
Inverse variance weighted	23	0.0661613	0.0420465	0.1155965
Simple mode	23	0.0617426	0.0957646	0.5257665
Weighted mode	23	0.0473013	0.0631218	0.4615751

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.54880	21	0.2241777
Inverse variance weighted	25.55104	22	0.2714560

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000267	0.0062235	0.9661829

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008614	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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