Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1207)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0617264	0.1104609	0.5822032
Weighted median	23	-0.0253655	0.0572044	0.6574625
Inverse variance weighted	23	-0.0475921	0.0422012	0.2594284
Simple mode	23	-0.0427153	0.1067768	0.6929829
Weighted mode	23	-0.0275534	0.0764953	0.7221344

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.71654	21	0.2174641
Inverse variance weighted	25.74021	22	0.2630033

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000868	0.0062438	0.8907618

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000825	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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