Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1206)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1922265	0.0998193	0.0677836
Weighted median	23	0.0718092	0.0596318	0.2285089
Inverse variance weighted	23	0.0377563	0.0390152	0.3331774
Simple mode	23	0.1624823	0.1111408	0.1578934
Weighted mode	23	0.1260901	0.0908260	0.1789565

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.56645	21	0.9705791
Inverse variance weighted	16.83202	22	0.7725637

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0141233	0.0056423	0.020639

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005384	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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