Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1205)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1399660	0.1047367	0.1957322
Weighted median	23	0.0303556	0.0536268	0.5713582
Inverse variance weighted	23	-0.0147805	0.0423788	0.7272605
Simple mode	23	0.0789736	0.0935513	0.4076580
Weighted mode	23	0.0735452	0.0579557	0.2177065

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.11975	21	0.3376268
Inverse variance weighted	25.95641	22	0.2535583

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0095029	0.0059202	0.1233902

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007909	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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