Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1204)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0180256	0.1017907	0.8611386
Weighted median	23	0.0203202	0.0568289	0.7206665
Inverse variance weighted	23	0.0278213	0.0390157	0.4757960
Simple mode	23	0.0253329	0.1030016	0.8080038
Weighted mode	23	0.0197162	0.0657489	0.7670906

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.83740	21	0.4089311
Inverse variance weighted	21.84877	22	0.4689458

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006016	0.0057537	0.9177242

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006775	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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