Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1203)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1898087	0.0998201	0.0710449
Weighted median	23	0.0198353	0.0553603	0.7201228
Inverse variance weighted	23	0.0372069	0.0390155	0.3402641
Simple mode	23	-0.0272880	0.0917326	0.7688963
Weighted mode	23	0.0528767	0.0660690	0.4320806

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.82646	21	0.9441846
Inverse variance weighted	14.58502	22	0.8794233

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093713	0.0056423	0.1115941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004695	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8