Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1202)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0508158	0.1013199	0.6212097
Weighted median	23	-0.0152714	0.0550837	0.7815962
Inverse variance weighted	23	0.0187735	0.0392007	0.6320040
Simple mode	23	-0.0234383	0.1004341	0.8176319
Weighted mode	23	-0.0266833	0.0675158	0.6964905

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.63567	21	0.4207587
Inverse variance weighted	22.20932	22	0.4474559

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042735	0.0057271	0.463827

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00068	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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