Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1201)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0504535	0.1190697	0.6760707
Weighted median	23	-0.0001468	0.0608916	0.9980769
Inverse variance weighted	23	0.0351426	0.0461249	0.4461188
Simple mode	23	0.0816766	0.1084581	0.4593910
Weighted mode	23	0.0282053	0.0792676	0.7253622

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.88054	21	0.094415
Inverse variance weighted	30.74845	22	0.101379

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052565	0.0067304	0.4435171

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009563	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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