Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1200)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0966316	0.0998206	0.3440357
Weighted median	23	0.0080273	0.0590799	0.8919225
Inverse variance weighted	23	-0.0294218	0.0390155	0.4507863
Simple mode	23	-0.1221075	0.1031012	0.2489143
Weighted mode	23	-0.0022716	0.0726484	0.9753369

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.06726	21	0.6447437
Inverse variance weighted	18.60235	22	0.6697378

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041274	0.0056424	0.4725609

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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