Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 120)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0156330	0.0998207	0.8770477
Weighted median	23	-0.0385450	0.0537557	0.4733494
Inverse variance weighted	23	-0.0253332	0.0390157	0.5161386
Simple mode	23	-0.1341987	0.0839830	0.1243240
Weighted mode	23	-0.0380062	0.0683183	0.5836131

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.86815	21	0.7770127
Inverse variance weighted	15.87930	22	0.8218307

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005957	0.0056423	0.9169214

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000494	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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