Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 12)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0906151	0.0998195	0.3742893
Weighted median	23	0.1056396	0.0543318	0.0518544
Inverse variance weighted	23	0.1015904	0.0390153	0.0092179
Simple mode	23	0.1399321	0.0996495	0.1742072
Weighted mode	23	0.1344611	0.0670275	0.0572994

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.64676	21	0.6712356
Inverse variance weighted	17.66102	22	0.7258863

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000674	0.0056423	0.9060511

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007406	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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