Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1199)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0399537	0.0998201	0.6930095
Weighted median	23	0.0255795	0.0558518	0.6469606
Inverse variance weighted	23	0.0294158	0.0390153	0.4508757
Simple mode	23	0.0656332	0.0998707	0.5178809
Weighted mode	23	0.0422420	0.0763352	0.5855868

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.82694	21	0.5962409
Inverse variance weighted	18.84009	22	0.6551810

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006471	0.0056423	0.9097782

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005881	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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