Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1198)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0983014	0.0998211	0.3359452
Weighted median	23	-0.0435367	0.0549047	0.4278061
Inverse variance weighted	23	0.0116427	0.0390157	0.7653890
Simple mode	23	-0.0569825	0.0892147	0.5296043
Weighted mode	23	-0.0424759	0.0646471	0.5179690

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.02946	21	0.9388191
Inverse variance weighted	13.46131	22	0.9194920

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067516	0.0056424	0.2447981

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004106	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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