Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1197)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0285357	0.1087376	0.7955492
Weighted median	23	-0.0308255	0.0646820	0.6336685
Inverse variance weighted	23	-0.0010397	0.0415986	0.9800605
Simple mode	23	0.0044533	0.1395328	0.9748270
Weighted mode	23	-0.0026096	0.1327191	0.9844901

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.92091	21	0.2506059
Inverse variance weighted	25.01047	22	0.2965744

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016886	0.0061465	0.7862159

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007579	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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