Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1196)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1687561	0.0998205	0.1057046
Weighted median	23	-0.0165547	0.0552173	0.7643221
Inverse variance weighted	23	-0.0347759	0.0390156	0.3727494
Simple mode	23	-0.0847863	0.0917848	0.3656375
Weighted mode	23	-0.0069976	0.0680892	0.9190757

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.139517	21	0.9880732
Inverse variance weighted	14.046610	22	0.8998167

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0124988	0.0056423	0.0379336

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004497	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8