Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1195)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0620707	0.0998212	0.5407535
Weighted median	23	0.0107345	0.0534355	0.8407867
Inverse variance weighted	23	0.0405189	0.0390158	0.2990248
Simple mode	23	0.0204332	0.0911877	0.8247640
Weighted mode	23	0.0013916	0.0633202	0.9826644

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.11173	21	0.8647521
Inverse variance weighted	15.35843	22	0.8464023

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063	0.0056424	0.2767979

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004981	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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