Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1194)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1041465	0.1126045	0.3655311
Weighted median	23	-0.1070395	0.0562247	0.0569386
Inverse variance weighted	23	-0.0695947	0.0431140	0.1064835
Simple mode	23	-0.1042364	0.0871325	0.2443144
Weighted mode	23	-0.0930322	0.0652324	0.1678576

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.72386	21	0.1801813
Inverse variance weighted	26.86528	22	0.2163879

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021218	0.006365	0.7421678

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009105	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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