Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1193)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0351148	0.1034095	0.7375524
Weighted median	23	-0.0007773	0.0580156	0.9893099
Inverse variance weighted	23	0.0321078	0.0399557	0.4216366
Simple mode	23	-0.0160297	0.1031173	0.8778831
Weighted mode	23	-0.0239903	0.0884606	0.7887678

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.53772	21	0.3691119
Inverse variance weighted	23.07303	22	0.3976158

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041282	0.0058452	0.4877984

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007197	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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