Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1192)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0611843	0.0998205	0.5464958
Weighted median	23	0.0269781	0.0538656	0.6164828
Inverse variance weighted	23	0.0412340	0.0390159	0.2905798
Simple mode	23	0.0509559	0.0875974	0.5666785
Weighted mode	23	0.0465059	0.0693860	0.5096740

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.177848	21	0.9877443
Inverse variance weighted	9.224995	22	0.9920755

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012251	0.0056423	0.8301996

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003134	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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