Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1191)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0063397	0.0998206	0.9499605
Weighted median	23	-0.0356996	0.0591492	0.5461417
Inverse variance weighted	23	-0.0058801	0.0390157	0.8802034
Simple mode	23	-0.0173954	0.0933860	0.8539367
Weighted mode	23	-0.0373070	0.0790966	0.6418111

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.03582	21	0.7089323
Inverse variance weighted	17.03585	22	0.7613802

Test for directional horizontal pleiotropy

egger_intercept	se	pval
2.82e-05	0.0056424	0.9960563

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005169	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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