Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1190)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0262219	0.1077828	0.8101454
Weighted median	23	-0.0534060	0.0593120	0.3678944
Inverse variance weighted	23	-0.0311556	0.0411617	0.4491057
Simple mode	23	-0.0051270	0.1043776	0.9612670
Weighted mode	23	-0.0398653	0.0656837	0.5501114

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.48391	21	0.2702073
Inverse variance weighted	24.48679	22	0.3222400

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000303	0.0060924	0.9608075

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007614	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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