Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 119)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1194131	0.0998191	0.2449143
Weighted median	23	0.0644511	0.0568105	0.2565879
Inverse variance weighted	23	0.0480302	0.0406138	0.2369654
Simple mode	23	0.0834440	0.0931619	0.3801155
Weighted mode	23	0.0605252	0.0700881	0.3971481

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.51861	21	0.4886580
Inverse variance weighted	23.83990	22	0.3556774

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0102827	0.0056423	0.0826606

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007683	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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